Serdemetan
1-N-[2-(1H-indol-3-yl)ethyl]-4-N-pyridin-4-ylbenzene-1,4-diamine
Molecular Identity
Serdemetan
1-N-[2-(1H-indol-3-yl)ethyl]-4-N-pyridin-4-ylbenzene-1,4-diamine
PubChem CID: 11609586
Serdemetan is an orally bioavailable HDM2 antagonist with potential antineoplastic activity. Serdemetan inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteasome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of p53 signaling and thus the p53-mediated induction of tumor cell apoptosis. HDM2 (human homolog of double minute 2), a zinc finger protein, is a negative regulator of the p53 pathway; often overexpressed in cancer cells, it has been implicated in cancer cell proliferation and survival.
2D Structure
Properties
C21H20N4
Molecular Formula
328.40
Molecular Weight
g/mol
328.1688
Exact Mass
Da
4.6
XLogP
Drug-like (Lipinski: < 5)
52.7
TPSA
Good oral absorption (< 140 A²)
3
H-Bond Donors
3
H-Bond Acceptors
387
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Serdemetan881202-45-5N1-(2-(1H-Indol-3-yl)ethyl)-N4-(pyridin-4-yl)benzene-1,4-diamineJNJ 26854165JNJ-26854165ID6YB4W3V8DTXSID30236830N-(2-(1H-Indol-3-yl)ethyl)-n'-(pyridin-4-yl)benzene-1,4-diamineserdemetanumRefChem:182499DTXCID60159321JNJ-26854165 (Serdemetan)Serdemetan [INN]JNJ26854165MFCD16620518
Data from PubChem (NCBI)
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