Pemafibrate
(2R)-2-[3-[[1,3-benzoxazol-2-yl-[3-(4-methoxyphenoxy)propyl]amino]methyl]phenoxy]butanoic acid
Molecular Identity
Pemafibrate
(2R)-2-[3-[[1,3-benzoxazol-2-yl-[3-(4-methoxyphenoxy)propyl]amino]methyl]phenoxy]butanoic acid
PubChem CID: 11526038
Pemafibrate is a member of the class of 1,3-benzoxazoles that is 1,3-benzoxazol-2-amine in which the amino hydrogens are replaced by 3-[(1R)-1-carboxypropoxy]benzyl and 3-(4-methoxyphenoxy)propyl groups. It is a selective peroxisome proliferator-activated receptor (PPAR)-alpha agonist that is used for the treatment of hyperlipidaemia. It has a role as an antilipemic drug, a hepatoprotective agent and a PPARalpha agonist. It is a monocarboxylic acid, an aromatic amine, a tertiary amino compound, a member of 1,3-benzoxazoles and a member of methoxybenzenes.
2D Structure
Properties
C28H30N2O6
Molecular Formula
490.50
Molecular Weight
g/mol
490.2104
Exact Mass
Da
6.2
XLogP
Above Lipinski threshold
94.3
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
8
H-Bond Acceptors
658
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Pemafibrate848259-27-8(R)-K-13675pemafibratoK-13675, (R)-17VGG92R23DTXSID00233891pemafibratum(2R)-2-(3-(((1,3-benzoxazol-2-yl)(3-(4-methoxyphenoxy)propyl)amino)methyl)phenoxy)butanoic acid(2R)-2-[3-({(1,3-Benzoxazol-2-yl)[3-(4-methoxyphenoxy)propyl]amino}methyl)phenoxy]butanoic acidRefChem:170729DTXCID30156382Pemafibrate [INN]MFCD30533427(R)-2-(3-((benzo[d]oxazol-2-yl(3-(4-methoxyphenoxy)propyl)amino)methyl)phenoxy)butanoic acid
Data from PubChem (NCBI)
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