KIN-3248
3-[2-(1-cyclopropyl-4,6-difluorobenzimidazol-5-yl)ethynyl]-1-[(3S,5R)-5-(methoxymethyl)-1-prop-2-enoylpyrrolidin-3-yl]-5-(methylamino)pyrazole-4-carboxamide
Molecular Identity
KIN-3248
3-[2-(1-cyclopropyl-4,6-difluorobenzimidazol-5-yl)ethynyl]-1-[(3S,5R)-5-(methoxymethyl)-1-prop-2-enoylpyrrolidin-3-yl]-5-(methylamino)pyrazole-4-carboxamide
PubChem CID: 162381323
2D Structure
Properties
C26H27F2N7O3
Molecular Formula
523.50
Molecular Weight
g/mol
523.2143
Exact Mass
Da
2.3
XLogP
Drug-like (Lipinski: < 5)
120
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
8
H-Bond Acceptors
1000
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
KIN-3248Pan-FGFR Inhibitor KIN-3248RefChem:858449Pan FGFR Inhibitor KIN-3248KIN 3248Pan-fibroblast Growth Factor Receptor Inhibitor KIN-3248Resigratinib2750709-91-01-((3S,5R)-1-Acryloyl-5-(methoxymethyl)pyrrolidin-3-yl)-3-((1-cyclopropyl-4,6-difluoro-1H-benzo[d]imidazol-5-yl)ethynyl)-5-(methylamino)-1H-pyrazole-4-carboxamideresigratinib [INN]orb2277619CHEMBL5314537SCHEMBL24463030GTPL12874KIN3248
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to KIN-3248
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