Tirbanibulin
N-benzyl-2-[5-[4-(2-morpholin-4-ylethoxy)phenyl]-2-pyridinyl]acetamide
Molecular Identity
Tirbanibulin
N-benzyl-2-[5-[4-(2-morpholin-4-ylethoxy)phenyl]-2-pyridinyl]acetamide
PubChem CID: 23635314
Tirbanibulin is a member of the class of pyridines that is pyridine substituted by 2-(benzylamino)-2-oxoethyl and 4-[2-(morpholin-4-yl)ethoxy]phenyl groups at positions 2 and 5, respectively. It is a dual inhibitor of Src kinase and tubulin and approved by the FDA for the topical treatment of actinic keratosis on the face or scalp. It has a role as an antineoplastic agent, a microtubule-destabilising agent, an apoptosis inducer and an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a secondary carboxamide, a member of pyridines, an aromatic ether and a member of morpholines.
2D Structure
Properties
C26H29N3O3
Molecular Formula
431.50
Molecular Weight
g/mol
431.2209
Exact Mass
Da
2.9
XLogP
Drug-like (Lipinski: < 5)
63.7
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
5
H-Bond Acceptors
540
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Tirbanibulin897016-82-9KX2-391KX-01N-benzyl-2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)acetamideKlisyriKX01KX-2-391tirbanibulinatirbanibulineKX-2391KX23914V9848RS5GN-benzyl-2-(5-{4-[2-(morpholin-4-yl)ethoxy]phenyl}pyridin-2-yl)acetamideDTXSID30237862
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Tirbanibulin
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