Lgh-447
N-[4-[(1R,3S,5S)-3-amino-5-methylcyclohexyl]-3-pyridinyl]-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide
Molecular Identity
Lgh-447
N-[4-[(1R,3S,5S)-3-amino-5-methylcyclohexyl]-3-pyridinyl]-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide
PubChem CID: 44814409
2D Structure
Properties
C24H23F3N4O
Molecular Formula
440.50
Molecular Weight
g/mol
440.1824
Exact Mass
Da
3.9
XLogP
Drug-like (Lipinski: < 5)
80.9
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
7
H-Bond Acceptors
630
Complexity
SMILES
Canonical SMILES
SMILES: CC1CC(CC(C1)N)C2=C(C=NC=C2)NC(=O)C3=NC(=C(C=C3)F)C4=C(C=CC=C4F)FIsomeric SMILES
SMILES: C[C@H]1C[C@H](C[C@H](C1)N)C2=C(C=NC=C2)NC(=O)C3=NC(=C(C=C3)F)C4=C(C=CC=C4F)FSynonyms(20)
PIM4471210608-43-7LGH-447LGH447PIM-447PIM 4479TG5O4V25HPim kinase inhibitor lgh447N-{4-[(1r,3s,5s)-3-Amino-5-Methylcyclohexyl]pyridin-3-Yl}-6-(2,6-Difluorophenyl)-5-Fluoropyridine-2-CarboxamideLGH 4472-Pyridinecarboxamide, N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)-3-pyridinyl)-6-(2,6-difluorophenyl)-5-fluoro-N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)-3-pyridinyl)-6-(2,6-difluorophenyl)-5-fluoro-2-pyridinecarboxamideN-[4-[(1R,3S,5S)-3-amino-5-methylcyclohexyl]pyridin-3-yl]-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamideN-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamideRefChem:153262
Data from PubChem (NCBI)
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