1243244-14-5
2-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-N-(5-pyrazin-2-yl-2-pyridinyl)acetamide
Molecular Identity
1243244-14-5
2-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-N-(5-pyrazin-2-yl-2-pyridinyl)acetamide
PubChem CID: 46926973
LGK974 is a carboxamide, the structure of which is that of acetamide substituted on carbon by a 2',3-dimethyl-2,4'-bipyridin-5-yl group and on nitrogen by a 5-(pyrazin-2-yl)pyridin-2-yl group. It is a highly potent, selective and orally bioavailable Porcupine inhibitor (a Wnt signalling inhibitor). It has a role as a Wnt signalling inhibitor. It is a secondary carboxamide, a member of pyridines, a member of pyrazines and a member of bipyridines. It is functionally related to an acetamide.
2D Structure
Properties
C23H20N6O
Molecular Formula
396.40
Molecular Weight
g/mol
396.1699
Exact Mass
Da
1.8
XLogP
Drug-like (Lipinski: < 5)
93.6
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
6
H-Bond Acceptors
560
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
1243244-14-5LGK974LGK-974WNT-974WNT974CHEBI:78030[2,4'-Bipyridine]-5-acetamide, 2',3-dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-U27F40013Q2-[5-methyl-6-(2-methylpyridin-4-yl)pyridin-3-yl]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide(2,4'-BIPYRIDINE)-5-ACETAMIDE, 2',3-DIMETHYL-N-(5-(2-PYRAZINYL)-2-PYRIDINYL)-2-(5-methyl-6-(2-methylpyridin-4-yl)pyridin-3-yl)-N-(5-pyrazin-2-ylpyridin-2-yl)acetamideRefChem:934231PORCN inhibitor LGK974Porcupine Inhibitor WNT9742-(2',3-dimethyl-(2,4'-bipyridine)-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide
Data from PubChem (NCBI)
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