Tasisulam
N-(5-bromothiophen-2-yl)sulfonyl-2,4-dichlorobenzamide
Molecular Identity
Tasisulam
N-(5-bromothiophen-2-yl)sulfonyl-2,4-dichlorobenzamide
PubChem CID: 10160238
Tasisulam is a thiophene substituted by a 2,4-dichlorobenzamide-N-sulfonyl and bromo groups at positions 2 and 4, respectively. It induces tumour cell apoptosis via ROS induction and mitochondrial membrane potential loss and currently in clinical development for the treatment of cancer. It has a role as an antineoplastic agent, an angiogenesis inhibitor and an apoptosis inducer. It is a dichlorobenzene, a member of thiophenes, an organobromine compound and a N-sulfonylcarboxamide.
2D Structure
Properties
C11H6BrCl2NO3S2
Molecular Formula
415.10
Molecular Weight
g/mol
412.8349
Exact Mass
Da
4.6
XLogP
Drug-like (Lipinski: < 5)
99.9
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
4
H-Bond Acceptors
471
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Tasisulam519055-62-0LY573636N-(2,4-Dichlorobenzoyl)-5-bromothiophene-2-sulfonamideLY-573636N-((5-BROMOTHIOPHEN-2-YL)SULFONYL)-2,4-DICHLOROBENZAMIDE1YC4W9MSLJN-[(5-bromothiophen-2-yl)sulfonyl]-2,4-dichlorobenzamideDTXSID20199869tasisulamumRefChem:187489DTXCID30122360965-512-7N-(5-bromothiophen-2-yl)sulfonyl-2,4-dichlorobenzamideLY 573636
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Tasisulam
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