Lasofoxifene
(5R,6S)-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol
Molecular Identity
Lasofoxifene
(5R,6S)-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol
PubChem CID: 216416
Lasofoxifene is a member of the class of tetralins that is 5,6,7,8-tetrahydronaphthalen-2-ol in which the hydrogens at positions 5 and 6 are replaced by 4-[2-(pyrrolidin-1-yl)ethoxy]phenyl and phenyl groups, respectively (the 5R,6S-stereoisomer). It is a selective estrogen receptor modulator indicated for the prevention and treatment of osteoporosis in post-menopausal women. It has a role as an antineoplastic agent, a bone density conservation agent, an estrogen receptor antagonist, an estrogen receptor agonist and a cardioprotective agent. It is a member of naphthols, an aromatic ether, a member of tetralins and a N-alkylpyrrolidine.
2D Structure
Properties
C28H31NO2
Molecular Formula
413.50
Molecular Weight
g/mol
413.2355
Exact Mass
Da
6.1
XLogP
Above Lipinski threshold
32.7
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
3
H-Bond Acceptors
533
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Lasofoxifene180916-16-9OporialasofoxifenoCP 336156lasofoxifenumCP-336,156(-)-cis-5,6,7,8-Tetrahydro-6-phenyl-5-(p-(2-(1-pyrrolidinyl)ethoxy)phenyl)-2-naphthol(5R,6S)-6-phenyl-5-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-5,6,7,8-tetrahydronaphthalen-2-ol(5R,6S)-6-phenyl-5-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-5,6,7,8-tetrahydronaphthalen-2-ol337G83N988CHEBI:135938DTXSID50171037RefChem:924541DTXCID8093528
Data from PubChem (NCBI)
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