Lenvatinib Mesylate
4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7-methoxyquinoline-6-carboxamide;methanesulfonic acid
Molecular Identity
Lenvatinib Mesylate
4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7-methoxyquinoline-6-carboxamide;methanesulfonic acid
PubChem CID: 11237762
Lenvatinib mesylate is a methanesulfonate salt obtained by reaction of lenvatinib with one molar equivalent of methanesulfonic acid. A multi-kinase inhibitor and orphan drug used (as its mesylate salt) for the treatment of various types of thyroid cancer that do not respond to radioiodine. It has a role as an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor, a fibroblast growth factor receptor antagonist, a vascular endothelial growth factor receptor antagonist and an orphan drug. It contains a lenvatinib(1+).
2D Structure
Properties
C22H23ClN4O7S
Molecular Formula
523.00
Molecular Weight
g/mol
522.0976
Exact Mass
Da
178
TPSA
May have limited oral absorption
4
H-Bond Donors
8
H-Bond Acceptors
727
Complexity
SMILES
Canonical SMILES
SMILES: COC1=CC2=NC=CC(=C2C=C1C(=O)N)OC3=CC(=C(C=C3)NC(=O)NC4CC4)Cl.CS(=O)(=O)OIsomeric SMILES
SMILES: COC1=CC2=NC=CC(=C2C=C1C(=O)N)OC3=CC(=C(C=C3)NC(=O)NC4CC4)Cl.CS(=O)(=O)OSynonyms(20)
LENVATINIB MESYLATE857890-39-2Lenvatinib mesilateE7080 MESYLATEE-7080 MESYLATELenvatinib methanesulfonate3J78384F61CHEBI:85995DTXSID90235081N-(4-((6-Carbamoyl-7-methoxyquinolin-4-yl)oxy)-2-chlorophenyl)-N'-cyclopropylurea monomethanesulfonate6-QUINOLINECARBOXAMIDE, 4-(3-CHLORO-4-(((CYCLOPROPYLAMINO)CARBONYL)AMINO)PHENOXY)-7-METHOXY-, METHANESULFONATE (1:1)RefChem:58937DTXCID90157572Multi-Kinase Inhibitor E7080 Mesylate4-(3-Chloro-4-(N'-cyclopropylureido)phenoxy)7-methoxyquinoline-6-carboxamide Mesylate
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Lenvatinib Mesylate
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