Levosulpiride
N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-methoxy-5-sulfamoylbenzamide
Molecular Identity
Levosulpiride
N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-methoxy-5-sulfamoylbenzamide
PubChem CID: 688272
(S)-(-)-sulpiride is an optically active form of sulpiride having (S)-configuration. The active enantiomer of the racemic drug sulpiride. Selective D2-like dopamine antagonist (Ki values are ~ 0.015. ~ 0.013, 1, ~ 45 and ~ 77 M at D2, D3, D4, D1 and D5 receptors respectively). It has a role as an antidepressant, an antipsychotic agent, a dopaminergic antagonist and an antiemetic. It is an enantiomer of a (R)-(+)-sulpiride.
2D Structure
Properties
C15H23N3O4S
Molecular Formula
341.40
Molecular Weight
g/mol
341.1409
Exact Mass
Da
0.6
XLogP
Drug-like (Lipinski: < 5)
110
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
6
H-Bond Acceptors
505
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Levosulpiride23672-07-3(-)-SulpirideLevopraidLevoprideL-SulpirideLevosulpiridaLevobrenlesurideLevosulpiridumSulpiride, (s)-Sulpiride, (-)-JTG7R315LK(-)-N-(((S)-1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide(S)-(-)-N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide
Data from PubChem (NCBI)
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