Molecular Identity
Loperamide
4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
PubChem CID: 3955
Loperamide is a synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease. It has a role as an anticoronaviral agent, a mu-opioid receptor agonist and an antidiarrhoeal drug. It is a member of piperidines, a tertiary alcohol, a monocarboxylic acid amide and a member of monochlorobenzenes. It is a conjugate base of a loperamide(1+).
2D Structure
Properties
C29H33ClN2O2
Molecular Formula
477.00
Molecular Weight
g/mol
476.2231
Exact Mass
Da
5
XLogP
Above Lipinski threshold
43.8
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
3
H-Bond Acceptors
623
Complexity
SMILES
Canonical SMILES
SMILES: CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4Isomeric SMILES
SMILES: CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4Synonyms(20)
loperamide53179-11-6LoperamidaLoperamidum4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamideFortasecDTXSID60451656X9OC3H4II4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N,N-dimethyl-2,2-diphenylbutanamide4-(4-Chlorophenyl)-N,N-dimethyl-alpha,alpha-diphenyl-4-hydroxy-1-piperidinebutanamideCHEBI:6532DTXCID40251651-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-NSC696356RefChem:5959
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Loperamide
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