Molecular Identity
Loratadine
ethyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate
PubChem CID: 3957
Loratadine is a benzocycloheptapyridine that is 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine substituted by a chloro group at position 8 and a 1-(ethoxycarbonyl)piperidin-4-ylidene group at position 11. It is a H1-receptor antagonist commonly employed in the treatment of allergic disorders. It has a role as a geroprotector, a H1-receptor antagonist, a cholinergic antagonist and an anti-allergic agent. It is a tertiary carboxamide, an ethyl ester, an organochlorine compound, a N-acylpiperidine and a benzocycloheptapyridine. It is functionally related to a desloratadine.
2D Structure
Properties
C22H23ClN2O2
Molecular Formula
382.90
Molecular Weight
g/mol
382.1448
Exact Mass
Da
5.2
XLogP
Above Lipinski threshold
42.4
TPSA
Good oral absorption (< 140 A²)
0
H-Bond Donors
3
H-Bond Acceptors
569
Complexity
SMILES
Canonical SMILES
SMILES: CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1Isomeric SMILES
SMILES: CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1Synonyms(20)
loratadine79794-75-5ClaritinClaritynAlavertClarityneFristaminLisinoBonalergLoracertLoradexClaritineHistaloranLertamineLorastine
Data from PubChem (NCBI)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Drug Network
Trials and conditions connected to Loratadine
Loading drug network...