Molecular Identity
losartan
[2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
PubChem CID: 3961
Losartan is a biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position. It has a role as an antihypertensive agent, an anti-arrhythmia drug, an endothelin receptor antagonist and an angiotensin receptor antagonist. It is a member of imidazoles and a biphenylyltetrazole. It is a conjugate acid of a losartan(1-).
2D Structure
Properties
C22H23ClN6O
Molecular Formula
422.90
Molecular Weight
g/mol
422.1622
Exact Mass
Da
4.3
XLogP
Drug-like (Lipinski: < 5)
92.5
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
5
H-Bond Acceptors
520
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
losartan114798-26-4allisartanAngizaarLosarticLozapDUP-89DTXSID7023227JMS50MPO89NSC-758699CHEBI:6541[2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanolHGP1405HGP-1405(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to losartan
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