Molecular Identity
Lucanthone
1-[2-(diethylamino)ethylamino]-4-methylthioxanthen-9-one
PubChem CID: 10180
Lucanthone is a thioxanthen-9-one compound having a methyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. Formerly used for the treatment of schistosomiasis. It is a prodrug, being metabolised to hycanthone. It has a role as a mutagen, an antineoplastic agent, a schistosomicide drug, a photosensitizing agent, a prodrug, an EC 5.99.1.2 (DNA topoisomerase) inhibitor, an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor and an adjuvant.
2D Structure
Properties
C20H24N2OS
Molecular Formula
340.50
Molecular Weight
g/mol
340.1609
Exact Mass
Da
4
XLogP
Drug-like (Lipinski: < 5)
57.6
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
4
H-Bond Acceptors
426
Complexity
SMILES
Canonical SMILES
SMILES: CCN(CC)CCNC1=C2C(=C(C=C1)C)SC3=CC=CC=C3C2=OIsomeric SMILES
SMILES: CCN(CC)CCNC1=C2C(=C(C=C1)C)SC3=CC=CC=C3C2=OSynonyms(20)
LUCANTHONE479-50-5LucanthonumLucantona1-((2-(Diethylamino)ethyl)amino)-4-methylthioxanthen-9-one1-((2-(diethylamino)ethyl)amino)-4-methyl-9H-thioxanthen-9-one1-{[2-(Diethylamino)ethyl]amino}-4-methyl-9H-thioxanthen-9-oneCHEBI:51052FC6D57000M9H-Thioxanthen-9-one, 1-((2-(diethylamino)ethyl)amino)-4-methyl-DTXSID60232301-diethylaminoethylethylamino-4-methyl-thioxanthenone1-{[2-(diethylamino)ethyl]amino}-4-methylthioxanthen-9-one9H-Thioxanthen-9-one, 1-[[2-(diethylamino)ethyl]amino]-4-methyl-RefChem:154184
Data from PubChem (NCBI)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Drug Network
Trials and conditions connected to Lucanthone
Loading drug network...