Lucitanib
6-[7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl]oxy-N-methylnaphthalene-1-carboxamide
Molecular Identity
Lucitanib
6-[7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl]oxy-N-methylnaphthalene-1-carboxamide
PubChem CID: 25031915
E-3810 free base is a naphthalenecarboxamide obtained from formal condensation of the carboxy group of aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl}oxy)-1-naphthoic acid with methylamine. It has a role as an antineoplastic agent, a fibroblast growth factor receptor antagonist and a vascular endothelial growth factor receptor antagonist. It is a member of quinolines, an aromatic ether, a naphthalenecarboxamide, a primary amino compound and a member of cyclopropanes. It is a conjugate base of an E-3810(1+).
2D Structure
Properties
C26H25N3O4
Molecular Formula
443.50
Molecular Weight
g/mol
443.1845
Exact Mass
Da
3.6
XLogP
Drug-like (Lipinski: < 5)
95.7
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
6
H-Bond Acceptors
686
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Lucitanib1058137-23-7E-3810E-3810 aminePP449XA4BHAL-3810CO-38106-({7-[(1-Aminocyclopropyl)methoxy]-6-Methoxyquinolin-4-Yl}oxy)-N-Methylnaphthalene-1-Carboxamide6-[7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl]oxy-N-methylnaphthalene-1-carboxamideDTXSID30147356S80881S-808811-Naphthalenecarboxamide, 6-((7-((1-aminocyclopropyl)methoxy)-6-methoxy-4-quinolinyl)oxy)-n-methyl-6-((7-((1-Aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yl)oxy)-n-methylnaphthalene-1-carboxamideCHEBI:65138
Data from PubChem (NCBI)
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