Lumefantrine
2-(dibutylamino)-1-[(9Z)-2,7-dichloro-9-[(4-chlorophenyl)methylidene]fluoren-4-yl]ethanol
Molecular Identity
Lumefantrine
2-(dibutylamino)-1-[(9Z)-2,7-dichloro-9-[(4-chlorophenyl)methylidene]fluoren-4-yl]ethanol
PubChem CID: 6437380
Lumefantrine is a member of the class of fluorenes that is 9-(p-chlorobenzylidene)-9H-fluorene which is substitutec by chlorine at positions 2 and 7, and by a 2-(dibutylamino)-1-hydroxyethyl group at position 4. An antimalarial drug used in combination with artemether for the treatment of multi-drug resistant strains of falciparum malaria. It has a role as an antimalarial. It is a member of fluorenes, a tertiary amine, a secondary alcohol and a member of monochlorobenzenes.
2D Structure
Properties
C30H32Cl3NO
Molecular Formula
528.90
Molecular Weight
g/mol
527.1549
Exact Mass
Da
8.7
XLogP
Above Lipinski threshold
23.5
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
2
H-Bond Acceptors
671
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
LumefantrineBenflumetol82186-77-4benflumelolGNF-Pf-1971LumefantrinaLumefantrinumDTXSID30466632-(dibutylamino)-1-[(9Z)-2,7-dichloro-9-[(4-chlorophenyl)methylidene]fluoren-4-yl]ethanolF38R0JR742(+-)-2,7-Dichloro-9-((Z)-p-chlorobenzylidene)-alpha-((dibutylamino)methyl)fluorene-4-methanolCPG-56695DTXCID1026663CHEBI:156095COARTEM COMPONENT LUMEFANTRINE
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Lumefantrine
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