MIK-665
(2R)-2-[5-[3-chloro-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-[2-(hydroxymethyl)phenyl]pyrimidin-4-yl]methoxy]phenyl]propanoic acid
Molecular Identity
MIK-665
(2R)-2-[5-[3-chloro-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-[2-(hydroxymethyl)phenyl]pyrimidin-4-yl]methoxy]phenyl]propanoic acid
PubChem CID: 118163156
2D Structure
Properties
C47H44ClFN6O6S
Molecular Formula
875.40
Molecular Weight
g/mol
874.2716
Exact Mass
Da
5.9
XLogP
Above Lipinski threshold
172
TPSA
May have limited oral absorption
2
H-Bond Donors
14
H-Bond Acceptors
1390
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(17)
MIK-665UNII-801XYWHNOSS64315(2R)-2-((5-((1P)-3-CHLORO-2-METHYL-4-(2-(4-METHYLPIPERAZIN-1-YL)ETHOXY)PHENYL)-6-(4-FLUOROPHENYL)THIENO(2,3-D)PYRIMIDIN-4-YL)OXY)-3-(2-((2-(2-METHOXYPHENYL)PYRIMIDIN-4-YL)METHOXY)PHENYL)PROPANOIC ACIDBENZENEPROPANOIC ACID, .ALPHA.-(((5S)-5-(3-CHLORO-2-METHYL-4-(2-(4-METHYL-1-PIPERAZINYL)ETHOXY)PHENYL)-6-(4-FLUOROPHENYL)THIENO(2,3-D)PYRIMIDIN-4-YL)OXY)-2-((2-(2-(HYDROXYMETHYL)PHENYL)-4-PYRIMIDINYL)METHOXY)-, (.ALPHA.R)-RefChem:158847Mcl-1 Inhibitor MIK665MIK 665BENZENEPROPANOIC ACID, ALPHA-(((5S)-5-(3-CHLORO-2-METHYL-4-(2-(4-METHYL-1-PIPERAZINYL)ETHOXY)PHENYL)-6-(4-FLUOROPHENYL)THIENO(2,3-D)PYRIMIDIN-4-YL)OXY)-2-((2-(2-(HYDROXYMETHYL)PHENYL)-4-PYRIMIDINYL)METHOXY)-, (ALPHAR)-1799631-75-6MIK665801XYWHNOS1799638-19-9CHEMBL4761750SCHEMBL16823352
Data from PubChem (NCBI)
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