MK-2206
8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-one
Molecular Identity
MK-2206
8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-one
PubChem CID: 24964624
MK-2206 is an organic heterotricyclic compound that is [1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one substituted by 4-(1-aminocyclobutyl)phenyl and phenyl groups at positions 8 and 9, respectively. It is an allosteric Akt inhibitor. It has a role as an autophagy inducer, an antineoplastic agent, an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor and an apoptosis inducer. It is a member of cyclobutanes, a member of benzenes, an organic heterotricyclic compound and a primary amino compound.
2D Structure
Properties
C25H21N5O
Molecular Formula
407.50
Molecular Weight
g/mol
407.1746
Exact Mass
Da
3
XLogP
Drug-like (Lipinski: < 5)
83.6
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
4
H-Bond Acceptors
760
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
MK-22068-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-oneMK 2206MK220651HZG6MP1KDTXCID0028874DTXSID3048948CHEBI:672711,2,4-Triazolo(3,4-f)(1,6)naphthyridin-3(2H)-one, 8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl(1,2,4)triazolo(3,4-f)(1,6)naphthyridin-3(2H)-one8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-2H-(1,2,4)triazolo(3,4-f)(1,6)naphthyridin-3-oneRefChem:5532191032349-77-14HA45S22ZZ
Data from PubChem (NCBI)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Drug Network
Trials and conditions connected to MK-2206
Loading drug network...