Mk-2206
8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-one
Molecular Identity
Mk-2206
8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-one
PubChem CID: 24964624
MK-2206 is an organic heterotricyclic compound that is [1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one substituted by 4-(1-aminocyclobutyl)phenyl and phenyl groups at positions 8 and 9, respectively. It is an allosteric Akt inhibitor. It has a role as an autophagy inducer, an antineoplastic agent, an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor and an apoptosis inducer. It is a member of cyclobutanes, a member of benzenes, an organic heterotricyclic compound and a primary amino compound.
2D Structure
Properties
C25H21N5O
Molecular Formula
407.50
Molecular Weight
g/mol
407.1746
Exact Mass
Da
3
XLogP
Drug-like (Lipinski: < 5)
83.6
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
4
H-Bond Acceptors
760
Complexity
SMILES
Canonical SMILES
SMILES: C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=N3)C=CN5C4=NNC5=O)C6=CC=CC=C6)NIsomeric SMILES
SMILES: C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=N3)C=CN5C4=NNC5=O)C6=CC=CC=C6)NSynonyms(20)
MK-2206MK22068-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-oneMK 220651HZG6MP1KDTXSID3048948DTXCID0028874CHEBI:672711032349-77-11,2,4-Triazolo(3,4-f)(1,6)naphthyridin-3(2H)-one, 8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl(1,2,4)triazolo(3,4-f)(1,6)naphthyridin-3(2H)-one8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-2H-(1,2,4)triazolo(3,4-f)(1,6)naphthyridin-3-oneRefChem:5532194HA45S22ZZ
Data from PubChem (NCBI)
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