Cariprazine
3-[4-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethylurea
Molecular Identity
Cariprazine
3-[4-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethylurea
PubChem CID: 11154555
Cariprazine is an N-alkylpiperazine that is N,N-dimethyl-N'-{trans-4-[2-(piperazin-1-yl)ethyl]cyclohexyl}urea substituted at position 4 on the piperazine ring by a 2,3-dichlorophenyl group. Used (as the hydrochloride salt) for treatment of schizophrenia and bipolar disorder. It has a role as a serotonergic antagonist, a dopamine agonist and a second generation antipsychotic. It is a dichlorobenzene, a N-alkylpiperazine, a N-arylpiperazine and a member of ureas. It is a conjugate base of a cariprazine(1+).
2D Structure
Properties
C21H32Cl2N4O
Molecular Formula
427.40
Molecular Weight
g/mol
426.1953
Exact Mass
Da
4.3
XLogP
Drug-like (Lipinski: < 5)
38.8
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
3
H-Bond Acceptors
491
Complexity
SMILES
Canonical SMILES
SMILES: CN(C)C(=O)NC1CCC(CC1)CCN2CCN(CC2)C3=C(C(=CC=C3)Cl)ClIsomeric SMILES
SMILES: CN(C)C(=O)NC1CCC(CC1)CCN2CCN(CC2)C3=C(C(=CC=C3)Cl)ClSynonyms(20)
Cariprazine839712-12-8RGH-1881480744-38-4RGH 188Cariprazine Cis IsomerCariprazine(RGH188)MP-214Cariprazine free base3-[4-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethylureaCariprazine (RGH-188)C21H32Cl2N4ON'-[trans-4-[2-[4-(2,3-Dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-N,N-dimethylureaF6RJL8B278CHEMBL3085826
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Cariprazine
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