MRTX-1719
2-[4-[4-(aminomethyl)-1-oxo-2H-phthalazin-6-yl]-1-methylpyrazol-5-yl]-4-chloro-6-cyclopropyloxy-3-fluorobenzonitrile
Molecular Identity
MRTX-1719
2-[4-[4-(aminomethyl)-1-oxo-2H-phthalazin-6-yl]-1-methylpyrazol-5-yl]-4-chloro-6-cyclopropyloxy-3-fluorobenzonitrile
PubChem CID: 156151242
2D Structure
Properties
C23H18ClFN6O2
Molecular Formula
464.90
Molecular Weight
g/mol
464.1164
Exact Mass
Da
2.7
XLogP
Drug-like (Lipinski: < 5)
118
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
7
H-Bond Acceptors
846
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
MRTX-17192630904-44-6MRTX1719Benzonitrile, 2-(4-(4-(aminomethyl)-1,2-dihydro-1-oxo-6-phthalazinyl)-1-methyl-1H-pyrazol-5-yl)-4-chloro-6-(cyclopropyloxy)-3-fluoro-, (2S)-(M)-272-[4-[4-(aminomethyl)-1-oxo-2H-phthalazin-6-yl]-2-methylpyrazol-3-yl]-4-chloro-6-cyclopropyloxy-3-fluorobenzonitrile2-(4-(4-(aminomethyl)-1-oxo-2H-phthalazin-6-yl)-2-methylpyrazol-3-yl)-4-chloro-6-cyclopropyloxy-3-fluorobenzonitrileRefChem:201848MRTX 1719PRMT5-MTA Inhibitor MRTX1719PRMT5-MTA Complex Inhibitor MRTX1719MTA-cooperative PRMT5 Inhibitor MRTX17192630904-45-7(S)-MRTX-1719Navlimetostat
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to MRTX-1719
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