Molecular Identity
memantine
3,5-dimethyladamantan-1-amine
PubChem CID: 4054
Memantine is a primary aliphatic amine that is the 3,5-dimethyl derivative of 1-aminoadamantane. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels. It has a role as an antidepressant, an antiparkinson drug, a dopaminergic agent, a NMDA receptor antagonist and a neuroprotective agent. It is a primary aliphatic amine and a member of adamantanes. It is a conjugate base of a memantinium(1+). It derives from a hydride of an adamantane.
2D Structure
Properties
C12H21N
Molecular Formula
179.30
Molecular Weight
g/mol
179.1674
Exact Mass
Da
3.3
XLogP
Drug-like (Lipinski: < 5)
26
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
1
H-Bond Acceptors
240
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
memantine19982-08-23,5-dimethyladamantan-1-amine1-Amino-3,5-dimethyladamantaneMemantina3,5-Dimethyl-1-adamantanamineMemantinum3,5-Dimethyl-1-aminoadamantane1,3-Dimethyl-5-adamantanaminenemdatineTricyclo[3.3.1.13,7]decan-1-amine, 3,5-dimethyl-DRG-02673,5-Dimethyltricyclo(3.3.1.1(3,7))decan-1-amineW8O17SJF3TDTXSID5045174
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to memantine
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