Molecular Identity
mianserin
5-methyl-2,5-diazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(19),8,10,12,15,17-hexaene
PubChem CID: 4184
Mianserin is a dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere. It has a role as a geroprotector, an antidepressant, an adrenergic uptake inhibitor, a histamine agonist, a sedative, an alpha-adrenergic antagonist, a H1-receptor antagonist, a serotonergic antagonist and an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor.
2D Structure
Properties
C18H20N2
Molecular Formula
264.40
Molecular Weight
g/mol
264.1626
Exact Mass
Da
3.4
XLogP
Drug-like (Lipinski: < 5)
6.5
TPSA
Good oral absorption (< 140 A²)
0
H-Bond Donors
2
H-Bond Acceptors
342
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
mianserinMianserine24219-97-4MianserinaMianserinumTolvon1,2,3,4,10,14b-Hexahydro-2-methyldibenzo(c,f)pyrazino(1,2-a)azepine250PJI13LMDTXSID6023317J16.389ICHEBI:51137DTXCID003317Dibenzo(c,f)pyrazino(1,2-a)azepine, 1,2,3,4,10,14b-hexahydro-2-methyl-1,2,3,4,10,14b-hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepineDibenzo[c,f]pyrazino[1,2-a]azepine, 1,2,3,4,10,14b-hexahydro-2-methyl-
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to mianserin
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