Molecular Identity
Naftifine
(E)-N-methyl-N-(naphthalen-1-ylmethyl)-3-phenylprop-2-en-1-amine
PubChem CID: 47641
Naftifine is a tertiary amine in which the nitrogen is substituted by methyl, alpha-naphthylmethyl, and (1E)-cinnamyl groups. It is used (usually as its hydrochloride salt) for the treatment of fungal skin infections. It has a role as an EC 1.14.13.132 (squalene monooxygenase) inhibitor and a sterol biosynthesis inhibitor. It is a member of naphthalenes, a tertiary amine and an allylamine antifungal drug.
2D Structure
Properties
C21H21N
Molecular Formula
287.40
Molecular Weight
g/mol
287.1674
Exact Mass
Da
5.1
XLogP
Above Lipinski threshold
3.2
TPSA
Good oral absorption (< 140 A²)
0
H-Bond Donors
1
H-Bond Acceptors
342
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Naftifine65472-88-0NaftifinaNaftifinumNaftifinNaft-5004FB1TON47ACHEBI:7451AW-105-843DTXSID6048545RefChem:57001methyl(naphthalen-1-ylmethyl)(3-phenylprop-2-en-1-yl)amineDTXCID6028101D01AE22(E)-Naftifine
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Naftifine
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