Trofinetide
(2S)-2-[[(2S)-1-(2-aminoacetyl)-2-methylpyrrolidine-2-carbonyl]amino]pentanedioic acid
Molecular Identity
Trofinetide
(2S)-2-[[(2S)-1-(2-aminoacetyl)-2-methylpyrrolidine-2-carbonyl]amino]pentanedioic acid
PubChem CID: 11318905
Trofinetide is a tripeptide comprising of glycine, 2-methyl-L-proline, and L-glutamic acid joined in sequence by peptide linkages. It is the first and only treatment approved by the FDA specifically indicated for Rett syndrome in adults and pediatric patients two years of age and older. It has a role as a neuroprotective agent and an anti-inflammatory agent. It is a secondary carboxamide, a tertiary carboxamide, a dicarboxylic acid, a pyrrolidinecarboxamide, a tripeptide and a primary amino compound. It is functionally related to a glycine and a L-glutamic acid.
2D Structure
Properties
C13H21N3O6
Molecular Formula
315.32
Molecular Weight
g/mol
315.1430
Exact Mass
Da
-3.9
XLogP
Drug-like (Lipinski: < 5)
150
TPSA
May have limited oral absorption
4
H-Bond Donors
7
H-Bond Acceptors
480
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Trofinetide853400-76-7NNZ-2566DAYBUEACP-2566trofinetidaL-Glutamic acid, glycyl-2-methyl-L-prolyl-Z2ME8F52QL(2S)-2-[[(2S)-1-(2-aminoacetyl)-2-methylpyrrolidine-2-carbonyl]amino]pentanedioic acidDTXSID101336041trofinetidum(2S)-2-(((2S)-1-(2-aminoacetyl)-2-methylpyrrolidine-2-carbonyl)amino)pentanedioic acidRefChem:59119DTXCID701766129(2S)-2-(((2S)-1-(2-aminoacetyl)-2-methylpyrrolidin-2-yl)formamido)pentanedioic acid
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Trofinetide
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