Molecular Identity
Methoxamine
2-amino-1-(2,5-dimethoxyphenyl)propan-1-ol
PubChem CID: 6082
Methoxamine is an amphetamine in which the parent 1-phenylpropan-2-amine skeleton is substituted at position 1 with an hydroxy group and the phenyl ring is 2- and 5-substituted with methoxy groups. It is an antihypotensive agent (pressor), an agonist acting directly at alpha-adrenoceptors with selectivity for the alpha-1 adrenoceptor subtype similar to phenylephrine. It has a role as an antihypotensive agent and an alpha-adrenergic agonist.
2D Structure
Properties
C11H17NO3
Molecular Formula
211.26
Molecular Weight
g/mol
211.1208
Exact Mass
Da
0.5
XLogP
Drug-like (Lipinski: < 5)
64.7
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
4
H-Bond Acceptors
189
Complexity
SMILES
Canonical SMILES
SMILES: CC(C(C1=C(C=CC(=C1)OC)OC)O)NIsomeric SMILES
SMILES: CC(C(C1=C(C=CC(=C1)OC)OC)O)NSynonyms(20)
methoxamineMethoxamin390-28-32-amino-1-(2,5-dimethoxyphenyl)propan-1-olMethoxamedrinePseudomethoxamineMetossaminaCHEBI:6839Benzenemethanol, alpha-(1-aminoethyl)-2,5-dimethoxy-NRL001DTXSID0023290NRL-001MethoxamedrinVasoxinWellcome, Metoxamine
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Methoxamine
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