NAPROXEN
(2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid
Molecular Identity
NAPROXEN
(2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid
PubChem CID: 156391
Naproxen is a methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6. Naproxen is a non-steroidal anti-inflammatory drug commonly used for the reduction of pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, kidney stones, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis, bursitis, and for the treatment of primary dysmenorrhea. It works by inhibiting both the COX-1 and COX-2 enzymes. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic, a xenobiotic, a gout suppressant, a cyclooxygenase 2 inhibitor, a cyclooxygenase 1 inhibitor, an environmental contaminant and a drug allergen. It is a monocarboxylic acid and a methoxynaphthalene. It is a conjugate acid of a naproxen(1-).
2D Structure
Properties
C14H14O3
Molecular Formula
230.26
Molecular Weight
g/mol
230.0943
Exact Mass
Da
3.3
XLogP
Drug-like (Lipinski: < 5)
46.5
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
3
H-Bond Acceptors
277
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
NAPROXEN22204-53-1(S)-Naproxen(+)-NaproxenNaprosynNaproxeneEquiproxen(S)-(+)-NaproxenNaproxenoNaixand-NaproxenEc-Naprosyn(S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid(+)-(S)-Naproxen(2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid
Data from PubChem (NCBI)
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