Molecular Identity
Niclosamide
5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
PubChem CID: 4477
Niclosamide is a secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections. It has a role as an anticoronaviral agent, a piscicide, a molluscicide, an antiparasitic agent, an anthelminthic drug, an apoptosis inducer and a STAT3 inhibitor. It is a secondary carboxamide, a member of benzamides, a C-nitro compound, a member of salicylanilides and a member of monochlorobenzenes. It is functionally related to a 5-chlorosalicylic acid.
2D Structure
Properties
C13H8Cl2N2O4
Molecular Formula
327.12
Molecular Weight
g/mol
325.9861
Exact Mass
Da
4
XLogP
Drug-like (Lipinski: < 5)
95.2
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
4
H-Bond Acceptors
404
Complexity
SMILES
Canonical SMILES
SMILES: C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)OIsomeric SMILES
SMILES: C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)OSynonyms(20)
niclosamide50-65-75-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamideNiclocideTredemineCestocidFenasalMansonilPhenasalVermitidYomesanLintexNasemoSulquiDevermin
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Niclosamide
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