Niraparib
2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide
Molecular Identity
Niraparib
2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide
PubChem CID: 24958200
Niraparib is a 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide that has S-configuration. It is a potent inhibitor of PARP1 and PARP2 (IC50 of 3.8 and 2.1 nM, respectively) and approved as a first-line maintenance treatment for women with advanced ovarian cancer after responding to platinum-based chemotherapy. It has a role as a radiosensitizing agent, an antineoplastic agent, an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor and an apoptosis inducer.
2D Structure
Properties
C19H20N4O
Molecular Formula
320.40
Molecular Weight
g/mol
320.1637
Exact Mass
Da
2.2
XLogP
Drug-like (Lipinski: < 5)
72.9
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
3
H-Bond Acceptors
449
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Niraparib1038915-60-4MK48272-{4-[(3s)-piperidin-3-yl]phenyl}-2h-indazole-7-carboxamide2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamideHMC2H89N35ZL-2306JNJ-64091742CHEBI:176844DTXSID50146129niraparibum2-(4-((3S)-piperidin-3-yl)phenyl)indazole-7-carboxamide2-(4-((3S)-PIPERIDIN-3-YL)PHENYL)-2H-INDAZOLE-7-CARBOXAMIDERefChem:57941DTXCID8068620
Data from PubChem (NCBI)
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Trials and conditions connected to Niraparib
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