Molecular Identity
Nitrazepam
7-nitro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
PubChem CID: 4506
Nitrazepam is a 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one which is substituted at positions 5 and 7 by phenyl and nitro groups, respectively. It is used as a hypnotic for the short-term management of insomnia and for the treatment of epileptic spasms in infants (West's syndrome). It has a role as an anticonvulsant, a sedative, a drug metabolite, a GABA modulator and an antispasmodic drug. It is a 1,4-benzodiazepinone and a C-nitro compound.
2D Structure
Properties
C15H11N3O3
Molecular Formula
281.27
Molecular Weight
g/mol
281.0800
Exact Mass
Da
2.2
XLogP
Drug-like (Lipinski: < 5)
87.3
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
4
H-Bond Acceptors
452
Complexity
SMILES
Canonical SMILES
SMILES: C1C(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])C(=N1)C3=CC=CC=C3Isomeric SMILES
SMILES: C1C(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])C(=N1)C3=CC=CC=C3Synonyms(20)
nitrazepamBenzalin146-22-5MogadonRadedormApodormCalsminEunoctinNeozepamNeuchlonicNitradosSonebonHipsalImesonRemnos
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Nitrazepam
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