ORIC-101
(8R,9S,10R,11S,13S,14S,17S)-17-(3,3-dimethylbut-1-ynyl)-17-hydroxy-13-methyl-11-[4-[methyl(propan-2-yl)amino]phenyl]-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
Molecular Identity
ORIC-101
(8R,9S,10R,11S,13S,14S,17S)-17-(3,3-dimethylbut-1-ynyl)-17-hydroxy-13-methyl-11-[4-[methyl(propan-2-yl)amino]phenyl]-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
PubChem CID: 134415769
2D Structure
Properties
C34H47NO2
Molecular Formula
501.70
Molecular Weight
g/mol
501.3607
Exact Mass
Da
6.9
XLogP
Above Lipinski threshold
40.5
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
3
H-Bond Acceptors
982
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
ORIC-101compound 28 [PMID: 30091920](8R,9S,10R,11S,13S,14S,17S)-17-(3,3-dimethylbut-1-ynyl)-17-hydroxy-13-methyl-11-[4-[methyl(propan-2-yl)amino]phenyl]-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-onecompound 28 (PMID: 30091920)(8R,9S,10R,11S,13S,14S,17S)-17-(3,3-dimethylbut-1-ynyl)-17-hydroxy-13-methyl-11-(4-(methyl(propan-2-yl)amino)phenyl)-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta(a)phenanthren-3-oneRefChem:168499GR Antagonist ORIC-101Glucocorticoid Receptor Antagonist ORIC-1012222344-98-9VI6E2D3CYPUNII-VI6E2D3CYPORIC101CHEMBL416175419,21-Dinorchol-4-en-20(22)-yn-3-one, 17-hydroxy-23,23-dimethyl-11-(4-(methyl(1-methylethyl)amino)phenyl)-, (11beta,17alpha)-orb1706866
Data from PubChem (NCBI)
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