Molecular Identity
Ofloxacin
7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid
PubChem CID: 4583
Ofloxacin is a racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. It has a role as an antiinfective agent, an antibacterial drug, an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, a topoisomerase IV inhibitor and a DNA synthesis inhibitor. It is a racemate, a quinolone antibiotic and a fluoroquinolone antibiotic. It contains a dextrofloxacin and a levofloxacin.
2D Structure
Properties
C18H20FN3O4
Molecular Formula
361.40
Molecular Weight
g/mol
361.1438
Exact Mass
Da
-0.4
XLogP
Drug-like (Lipinski: < 5)
73.3
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
8
H-Bond Acceptors
634
Complexity
SMILES
Canonical SMILES
SMILES: CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)OIsomeric SMILES
SMILES: CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)OSynonyms(20)
ofloxacin82419-36-1FloxinOfloxacineTarividOcufloxOfloxacinoVisirenOfloxacinumDL-8280OfloxacinaExocinHoe-280Floxin oticOfloxacin Otic
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Ofloxacin
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