Buparlisib
5-(2,6-dimorpholin-4-ylpyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-amine
Molecular Identity
Buparlisib
5-(2,6-dimorpholin-4-ylpyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-amine
PubChem CID: 16654980
BKM120 is an aminopyridine that is 4-(trifluoromethyl)pyridin-2-amine substituted at position 5 by a 2,6-di(morpholin-4-yl)pyrimidin-4-y group. A selective PI3K inhibitor with anti-tumour properties. It has a role as an antineoplastic agent and an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor. It is an organofluorine compound, an aminopyridine, an aminopyrimidine and a member of morpholines.
2D Structure
Properties
C18H21F3N6O2
Molecular Formula
410.40
Molecular Weight
g/mol
410.1678
Exact Mass
Da
1.5
XLogP
Drug-like (Lipinski: < 5)
89.6
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
11
H-Bond Acceptors
530
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Buparlisib944396-07-0NVP-BKM120BKM-120NVP-BKM-120BKM 120BKM-120NXBKM120-NX0ZM2Z182GDDTXSID50241486buparlisibumRefChem:570492PI3K Inhibitor BKM120DTXCID50163977AN2025
Data from PubChem (NCBI)
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Trials and conditions connected to Buparlisib
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