Plx-5622
6-fluoro-N-[(5-fluoro-2-methoxy-3-pyridinyl)methyl]-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]pyridin-2-amine
Molecular Identity
Plx-5622
6-fluoro-N-[(5-fluoro-2-methoxy-3-pyridinyl)methyl]-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]pyridin-2-amine
PubChem CID: 52936034
PLX5622 is a highly selective brain penetrant and orally active CSF1R inhibitor. PLX5622 allows for extended and specific microglial cells elimination, preceding and during pathology development. PLX5622 demonstrates desirable PK properties in varies animals. PLX5622 is mostly used in the way of feed free diet.
2D Structure
Properties
C21H19F2N5O
Molecular Formula
395.40
Molecular Weight
g/mol
395.1558
Exact Mass
Da
4.1
XLogP
Drug-like (Lipinski: < 5)
75.7
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
7
H-Bond Acceptors
529
Complexity
SMILES
Canonical SMILES
SMILES: CC1=CC2=C(NC=C2CC3=C(N=C(C=C3)NCC4=C(N=CC(=C4)F)OC)F)N=C1Isomeric SMILES
SMILES: CC1=CC2=C(NC=C2CC3=C(N=C(C=C3)NCC4=C(N=CC(=C4)F)OC)F)N=C1Synonyms(20)
1303420-67-8PLX56226-Fluoro-N-((5-fluoro-2-methoxypyridin-3-yl)methyl)-5-((5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)pyridin-2-aminePLX-56226-fluoro-N-[(5-fluoro-2-methoxypyridin-3-yl)methyl]-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]pyridin-2-amine16A8IGR8L73-Pyridinemethanamine, 5-fluoro-N-(6-fluoro-5-((5-methyl-1H-pyrrolo(2,3-b)pyridin-3-yl)methyl)-2-pyridinyl)-2-methoxy-5-Fluoro-N-(6-fluoro-5-((5-methyl-1H-pyrrolo(2,3-b)pyridin-3-yl)methyl)-2-pyridinyl)-2-methoxy-3-pyridinemethanamine5-fluoro-N-[6-fluoro-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-2-methoxy-3-pyridinemethanamine6-fluoro-N-((5-fluoro-2-methoxypyridin-3-yl)methyl)-5-((5-methyl-1H-pyrrolo(2,3-b)pyridin-3-yl)methyl)pyridin-2-amineRefChem:174940PLX5622 free baseMFCD32201039HY-114153C21H19F2N5O
Data from PubChem (NCBI)
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