Pomalidomide
4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
Molecular Identity
Pomalidomide
4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
PubChem CID: 134780
Pomalidomide is an aromatic amine that is thalidomide substituted at position 4 on the isoindole ring system by an amino group. Used for the treatment of multiple myeloma in patients who failed to respond to previous therapies. It has a role as an antineoplastic agent, an angiogenesis inhibitor and an immunomodulator. It is a member of isoindoles, an aromatic amine, a dicarboximide and a member of piperidones. It is functionally related to a thalidomide.
2D Structure
Properties
C13H11N3O4
Molecular Formula
273.24
Molecular Weight
g/mol
273.0750
Exact Mass
Da
0.2
XLogP
Drug-like (Lipinski: < 5)
110
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
5
H-Bond Acceptors
504
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Pomalidomide19171-19-8ActimidCC-4047PomalystImnovid4-Aminothalidomide4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimideIMiD 3CC 4047IMID-34-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dioneIMiD3
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Pomalidomide
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