Poziotinib
1-[4-[4-(3,4-dichloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]prop-2-en-1-one
Molecular Identity
Poziotinib
1-[4-[4-(3,4-dichloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]prop-2-en-1-one
PubChem CID: 25127713
2D Structure
Properties
C23H21Cl2FN4O3
Molecular Formula
491.30
Molecular Weight
g/mol
490.0975
Exact Mass
Da
5.4
XLogP
Above Lipinski threshold
76.6
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
7
H-Bond Acceptors
684
Complexity
SMILES
Canonical SMILES
SMILES: COC1=C(C=C2C(=C1)N=CN=C2NC3=C(C(=C(C=C3)Cl)Cl)F)OC4CCN(CC4)C(=O)C=CIsomeric SMILES
SMILES: COC1=C(C=C2C(=C1)N=CN=C2NC3=C(C(=C(C=C3)Cl)Cl)F)OC4CCN(CC4)C(=O)C=CSynonyms(20)
Poziotinib1092364-38-91-(4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)prop-2-en-1-oneNOV120101NOV-120101HM-781-36B1-[4-[4-(3,4-dichloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]prop-2-en-1-oneNOV-1201poziotinibumOEI6OOU6IKHM 781-36BHM-781-36DTXSID801488531-[4-({4-[(3,4-DICHLORO-2-FLUOROPHENYL)AMINO]-7-METHOXYQUINAZOLIN-6-YL}OXY)PIPERIDIN-1-YL]PROP-2-EN-1-ONE1-(4-(4-(3,4-dichloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl)oxypiperidin-1-yl)prop-2-en-1-one
Data from PubChem (NCBI)
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