Vatalanib
N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine
Molecular Identity
Vatalanib
N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine
PubChem CID: 151194
Vatalanib is a member of the class of phthalazines that is phthalazine in which the hydrogens at positions 1 and 4have been replaced by a p-chlorophenylamino group and a pyridin-4-ylmethyl group, respectively. It is a multi-targeted tyrosine kinase inhibitor for all isoforms of VEGFR, PDGFR and c-Kit. It has a role as an antineoplastic agent, an angiogenesis inhibitor, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and a vascular endothelial growth factor receptor antagonist. It is a member of pyridines, a member of phthalazines, a secondary amino compound and a member of monochlorobenzenes.
2D Structure
Properties
C20H15ClN4
Molecular Formula
346.80
Molecular Weight
g/mol
346.0985
Exact Mass
Da
4.5
XLogP
Drug-like (Lipinski: < 5)
50.7
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
4
H-Bond Acceptors
407
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Vatalanib212141-54-3N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-aminePynasunateVatalinibPTK787CGP 79787CGP-79787ZK-232934NVP-PTK787DTXSID2046919ZK2225845DX9U76296BAY-86-5127N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Vatalanib
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