Pazopanib
5-[[4-[(2,3-dimethylindazol-6-yl)-methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide
Molecular Identity
Pazopanib
5-[[4-[(2,3-dimethylindazol-6-yl)-methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide
PubChem CID: 10113978
Pazopanib is a pyrimidine that is 5-(pyrimidin-2-yl}amino-2-methylbenzenesulfonamide substituted at position 4 by a (2,3-dimethylindazol-6-yl)(methyl)amino group. Used as its hydrochloride salt for treatment of kidney cancer. It has a role as an antineoplastic agent, a tyrosine kinase inhibitor, an angiogenesis modulating agent and a vascular endothelial growth factor receptor antagonist. It is a sulfonamide, an aminopyrimidine and a member of indazoles. It is a conjugate base of a pazopanib(1+).
2D Structure
Properties
C21H23N7O2S
Molecular Formula
437.50
Molecular Weight
g/mol
437.1634
Exact Mass
Da
3.1
XLogP
Drug-like (Lipinski: < 5)
127
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
8
H-Bond Acceptors
717
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Pazopanib444731-52-6GW7860345-((4-((2,3-dimethyl-2H-indazol-6-yl)(methyl)amino)pyrimidin-2-yl)amino)-2-methylbenzenesulfonamidepazopanibum7RN5DR86CKNSC-752782DTXSID8048733GW780604GW-7806045-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamideDTXCID1028659CHEBI:71219Benzenesulfonamide, 5-((4-((2,3-dimethyl-2H-indazol-6-yl)methylamino)-2-pyrimidinyl)amino)-2-methyl-5-({4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide
Data from PubChem (NCBI)
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Drug Network
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