Molecular Identity
Phenformin
1-(diaminomethylidene)-2-(2-phenylethyl)guanidine
PubChem CID: 8249
Phenformin is a member of the class of biguanides that is biguanide in which one of the terminal nitrogen atoms is substituted by a 2-phenylethyl group. It was used as an anti-diabetic drug but was later withdrawn from the market due to potential risk of lactic acidosis. It has a role as a geroprotector, a hypoglycemic agent and an antineoplastic agent. It is functionally related to a biguanide.
2D Structure
Properties
C10H15N5
Molecular Formula
205.26
Molecular Weight
g/mol
205.1327
Exact Mass
Da
-0.8
XLogP
Drug-like (Lipinski: < 5)
103
TPSA
Good oral absorption (< 140 A²)
3
H-Bond Donors
1
H-Bond Acceptors
236
Complexity
SMILES
Canonical SMILES
SMILES: C1=CC=C(C=C1)CCN=C(N)N=C(N)NIsomeric SMILES
SMILES: C1=CC=C(C=C1)CCN=C(N)N=C(N)NSynonyms(20)
PHENFORMIN114-86-3PhenformineFenforminFenforminaPedgPhenethyldiguanidePhenformixFenorminPhenylethylbiguanideCronoforminFenfoduronGlukopostinDebeoneDiabis
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Phenformin
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