Molecular Identity
proglumide
4-benzamido-5-(dipropylamino)-5-oxopentanoic acid
PubChem CID: 4922
Proglumide is a racemate composed of equal amounts of (R)- and (S)-proglumide. A non-selective CCK antagonist that was used primarily for treatment of stomach ulcers, but has been replaced by newer drugs. It has a role as an opioid analgesic, a cholinergic antagonist, a drug metabolite, an anti-ulcer drug, a gastrointestinal drug, a delta-opioid receptor agonist, a cholecystokinin antagonist and a xenobiotic metabolite. It contains a (R)-proglumide and a (S)-proglumide.
2D Structure
Properties
C18H26N2O4
Molecular Formula
334.40
Molecular Weight
g/mol
334.1893
Exact Mass
Da
2.4
XLogP
Drug-like (Lipinski: < 5)
86.7
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
4
H-Bond Acceptors
413
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
proglumide6620-60-64-benzamido-5-(dipropylamino)-5-oxopentanoic acidBinosideXylamidedl-proglumideMilidNulsaGastrotopicMidelidUlcutinProglumidaXydeProglumidumPromid
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to proglumide
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