Proguanil
(1E)-1-[amino-(4-chloroanilino)methylidene]-2-propan-2-ylguanidine
Molecular Identity
Proguanil
(1E)-1-[amino-(4-chloroanilino)methylidene]-2-propan-2-ylguanidine
PubChem CID: 6178111
Proguanil is a biguanide compound which has isopropyl and p-chlorophenyl substituents on the terminal N atoms. A prophylactic antimalarial drug, it works by inhibiting the enzyme dihydrofolate reductase, which is involved in the reproduction of the malaria parasites Plasmodium falciparum and P. vivax within the red blood cells. It has a role as an antiprotozoal drug, an antimalarial and an EC 1.5.1.3 (dihydrofolate reductase) inhibitor. It is a member of biguanides and a member of monochlorobenzenes.
2D Structure
Properties
C11H16ClN5
Molecular Formula
253.73
Molecular Weight
g/mol
253.1094
Exact Mass
Da
1.5
XLogP
Drug-like (Lipinski: < 5)
88.8
TPSA
Good oral absorption (< 140 A²)
3
H-Bond Donors
1
H-Bond Acceptors
292
Complexity
SMILES
Canonical SMILES
SMILES: CC(C)N=C(N)N=C(N)NC1=CC=C(C=C1)ClIsomeric SMILES
SMILES: CC(C)N=C(N)/N=C(\N)/NC1=CC=C(C=C1)ClSynonyms(20)
proguanilChloroguanideChlorguanideBigumalChlorguanidPaludrin500-92-5Proguanilum1-(p-Chlorophenyl)-5-isopropylbiguanideProguanileCHEBI:8455N-(4-Chlorophenyl)-N'-(isopropyl)-imidodicarbonimidic diamideS61K3P7B2VImidodicarbonimidic diamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-DTXSID3022794
Data from PubChem (NCBI)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Drug Network
Trials and conditions connected to Proguanil
Loading drug network...