QUISINOSTAT
N-hydroxy-2-[4-[[(1-methylindol-3-yl)methylamino]methyl]piperidin-1-yl]pyrimidine-5-carboxamide
Molecular Identity
QUISINOSTAT
N-hydroxy-2-[4-[[(1-methylindol-3-yl)methylamino]methyl]piperidin-1-yl]pyrimidine-5-carboxamide
PubChem CID: 11538455
Quisinostat is a member of the class of methylindoles that is 1H-indole substituted by methyl and [({1-[5-(hydroxycarbamoyl)pyrimidin-2-yl]piperidin-4-yl}methyl)amino]methyl groups at positions 1 and 3, respectively. It is an orally bioavailable pan-HDAC inhibitor that exhibits antineoplastic activity. It has a role as a radiosensitizing agent, an autophagy inducer, an antineoplastic agent, an antimalarial, a bone density conservation agent and an EC 3.5.1.98 (histone deacetylase) inhibitor. It is a hydroxamic acid, a member of piperidines, a methylindole, a member of pyrimidines and a secondary amino compound.
2D Structure
Properties
C21H26N6O2
Molecular Formula
394.50
Molecular Weight
g/mol
394.2117
Exact Mass
Da
1.3
XLogP
Drug-like (Lipinski: < 5)
95.3
TPSA
Good oral absorption (< 140 A²)
3
H-Bond Donors
6
H-Bond Acceptors
533
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
QUISINOSTAT875320-29-9JNJ-26481585N-Hydroxy-2-(4-((((1-methyl-1H-indol-3-yl)methyl)amino)methyl)piperidin-1-yl)pyrimidine-5-carboxamide9BJ85K1J8SJNJ 26481585N-hydroxy-2-[4-[[(1-methylindol-3-yl)methylamino]methyl]piperidin-1-yl]pyrimidine-5-carboxamideDTXSID902363765-Pyrimidinecarboxamide, N-hydroxy-2-(4-((((1-methyl-1H-indol-3-yl)methyl)amino)methyl)-1-piperidinyl)-N-Hydroxy-2-[4-({[(1-methyl-1H-indol-3-yl)methyl]amino}methyl)piperidin-1-yl]pyrimidine-5-carboxamideJNJ26481585quisinostatumN-hydroxy-2-(4-(((1-methylindol-3-yl)methylamino)methyl)piperidin-1-yl)pyrimidine-5-carboxamideRefChem:930503DTXCID90158867
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to QUISINOSTAT
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