Raf265

Raf265

1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine

PubChem CID: 11656518

CHIR-265 is a member of the class of benzimidazoles that is 1H-benzimidazole substituted by methyl, [4-(trifluoromethyl)phenyl]amino, and {2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl}oxy groups at positions 1, 2, and 5, respectively. It is an inhibitor of RAF kinases, including the BRAF V600E mutant. It has a role as an antiviral agent, an antineoplastic agent, an angiogenesis inhibitor, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor, an apoptosis inducer and a B-Raf inhibitor. It is a member of benzimidazoles, a member of imidazoles, a member of pyridines, an aromatic ether, an organofluorine compound, a substituted aniline and a member of (trifluoromethyl)benzenes.

2D Structure

Properties

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Synonyms(20)