Retigabine
ethyl N-[2-amino-4-[(4-fluorophenyl)methylamino]phenyl]carbamate
Molecular Identity
Retigabine
ethyl N-[2-amino-4-[(4-fluorophenyl)methylamino]phenyl]carbamate
PubChem CID: 121892
Ezogabine is a substituted aniline that is benzene-1,2,4-triamine bearing ethoxycarbonyl and 4-fluorobenzyl substituents at positions N-1 and N-4 respectively. An anticonvulsant used to treat seizures associated with epilepsy in adults. It has a role as an anticonvulsant and a potassium channel modulator. It is a carbamate ester, an organofluorine compound, a substituted aniline and a secondary amino compound. It is functionally related to a benzene-1,2,4-triamine.
2D Structure
Properties
C16H18FN3O2
Molecular Formula
303.33
Molecular Weight
g/mol
303.1383
Exact Mass
Da
2.8
XLogP
Drug-like (Lipinski: < 5)
76.4
TPSA
Good oral absorption (< 140 A²)
3
H-Bond Donors
5
H-Bond Acceptors
348
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Retigabine150812-12-7EzogabinePotigaTrobaltD-23129GKE-841WAY-143841N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl esterEthyl 2-amino-4-((p-fluorobenzyl)amino)carbanilateRetigabinaethyl N-[2-amino-4-[(4-fluorophenyl)methylamino]phenyl]carbamateAWD-21360AWD21-360GW582892X
Data from PubChem (NCBI)
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