Ricolinostat
N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)pyrimidine-5-carboxamide
Molecular Identity
Ricolinostat
N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)pyrimidine-5-carboxamide
PubChem CID: 53340666
Ricolinostat is a member of the class of pyrimidines that is pyrimidine substituted by diphenylamino and [7-(hydroxyamino)-7-oxoheptyl]aminocarbonyl groups at positions 2 and 5, respectively. It is a histone deacetylase 6 inhibitor with potential antineoplastic activity. It has a role as an antineoplastic agent, an EC 3.5.1.98 (histone deacetylase) inhibitor, an anti-inflammatory agent and an apoptosis inducer. It is a secondary carboxamide, a hydroxamic acid, a pyrimidinecarboxamide, a substituted aniline and a tertiary amino compound.
2D Structure
Properties
C24H27N5O3
Molecular Formula
433.50
Molecular Weight
g/mol
433.2114
Exact Mass
Da
3.4
XLogP
Drug-like (Lipinski: < 5)
107
TPSA
Good oral absorption (< 140 A²)
3
H-Bond Donors
6
H-Bond Acceptors
538
Complexity
SMILES
Canonical SMILES
SMILES: C1=CC=C(C=C1)N(C2=CC=CC=C2)C3=NC=C(C=N3)C(=O)NCCCCCCC(=O)NOIsomeric SMILES
SMILES: C1=CC=C(C=C1)N(C2=CC=CC=C2)C3=NC=C(C=N3)C(=O)NCCCCCCC(=O)NOSynonyms(20)
1316214-52-4RicolinostatACY-12152-(Diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamideACY-63WKT909C62BN-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)pyrimidine-5-carboxamide2-(diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]pyrimidine-5-carboxamideDTXSID401571487-{[2-(DIPHENYLAMINO)PYRIMIDIN-5-YL]FORMAMIDO}-N-HYDROXYHEPTANAMIDEricolinostatum7-((2-(diphenylamino)pyrimidin-5-yl)formamido)-N-hydroxyheptanamideN-(7-(hydroxyamino)-7-oxoheptyl)-2-(N-phenylanilino)pyrimidine-5-carboxamideRefChem:883628DTXCID0079639
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Ricolinostat
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