Rigosertib Sodium
sodium 2-[2-methoxy-5-[[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonylmethyl]anilino]acetate
Molecular Identity
Rigosertib Sodium
sodium 2-[2-methoxy-5-[[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonylmethyl]anilino]acetate
PubChem CID: 23696523
Rigosertib sodium is the sodium salt of rigosertib. It is an anti-cancer agent which has been granted Orphan Drug Designation by the FDA for use in patients with myelodysplastic syndromes (MDS). It has a role as an EC 2.7.11.21 (polo kinase) inhibitor, an antineoplastic agent, a microtubule-destabilising agent and an apoptosis inducer. It contains a rigosertib(1-).
2D Structure
Properties
C21H24NNaO8S
Molecular Formula
473.50
Molecular Weight
g/mol
473.1120
Exact Mass
Da
132
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
9
H-Bond Acceptors
684
Complexity
SMILES
Canonical SMILES
SMILES: COC1=C(C=C(C=C1)CS(=O)(=O)C=CC2=C(C=C(C=C2OC)OC)OC)NCC(=O)[O-].[Na+]Isomeric SMILES
SMILES: COC1=C(C=C(C=C1)CS(=O)(=O)/C=C/C2=C(C=C(C=C2OC)OC)OC)NCC(=O)[O-].[Na+]Synonyms(20)
Rigosertib sodium592542-60-4EstybonNovonexON-01910 sodiumON01910 sodiumON 01910 sodium saltON 01910.NaON 01910 sodiumSyB C-1101ON-01910.Na406FL5G00VCHEBI:145421RefChem:930770Polo-like kinase 1 Inhibitor ON 01910.Na
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Rigosertib Sodium
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