Molecular Identity
rolipram
4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
PubChem CID: 5092
Rolipram is a member of the lclass of pyrrolidin-2-ones that is pyrrolidin-2-one bearing a 3-(cyclopentyloxy)-4-methoxyphenyl substituent at the 4-position. It is a type IV-specific phosphodiesterase (PDE4) inhibitor. It has a role as an antidepressant and an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor.
2D Structure
Properties
C16H21NO3
Molecular Formula
275.34
Molecular Weight
g/mol
275.1521
Exact Mass
Da
2.2
XLogP
Drug-like (Lipinski: < 5)
47.6
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
3
H-Bond Acceptors
341
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
rolipram61413-54-5(R,S)-rolipramZK 627114-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-oneRolipramumZK-627114-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-oneNSC-7601254-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-pyrrolidinoneZK 62 711SB-95952ZK-62771K676NL63N7
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to rolipram
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