Apilimod
N-[(E)-(3-methylphenyl)methylideneamino]-6-morpholin-4-yl-2-(2-pyridin-2-ylethoxy)pyrimidin-4-amine
Molecular Identity
Apilimod
N-[(E)-(3-methylphenyl)methylideneamino]-6-morpholin-4-yl-2-(2-pyridin-2-ylethoxy)pyrimidin-4-amine
PubChem CID: 10173277
Apilimod (STA 5326) is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 in IFNg/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs. Apilimod is a potent and highly selective PIKfyve inhibitor.
2D Structure
Properties
C23H26N6O2
Molecular Formula
418.50
Molecular Weight
g/mol
418.2117
Exact Mass
Da
3.8
XLogP
Drug-like (Lipinski: < 5)
84.8
TPSA
Good oral absorption (< 140 A²)
1
H-Bond Donors
8
H-Bond Acceptors
544
Complexity
SMILES
Canonical SMILES
SMILES: CC1=CC(=CC=C1)C=NNC2=CC(=NC(=N2)OCCC3=CC=CC=N3)N4CCOCC4Isomeric SMILES
SMILES: CC1=CC(=CC=C1)/C=N/NC2=CC(=NC(=N2)OCCC3=CC=CC=N3)N4CCOCC4Synonyms(20)
Apilimod541550-19-0STA-5326STA 5326STA5326GFW2K84S4LN-[(3-methylphenyl)methylideneamino]-6-morpholin-4-yl-2-(2-pyridin-2-ylethoxy)pyrimidin-4-amineBENZALDEHYDE, 3-METHYL-, (6-(4-MORPHOLINYL)-2-(2-(2-PYRIDINYL)ETHOXY)-4-PYRIMIDINYL)HYDRAZONEN-(3-METHYL-BENZYLIDENE)-N'-(6-MORPHOLIN-4-YL-2-(2-PYRIDIN-2-YL-ETHOXY)-PYRIMIDIN-4-YL)-HYDRAZINEapilimodumDTXSID101025733apilimod bismesylateN-((3-methylphenyl)methylideneamino)-6-morpholin-4-yl-2-(2-pyridin-2-ylethoxy)pyrimidin-4-amineRefChem:113408DTXCID101509995
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Apilimod
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