Molecular Identity
Salsalate
2-(2-hydroxybenzoyl)oxybenzoic acid
PubChem CID: 5161
Salsalate is a dimeric benzoate ester obtained by intermolecular condensation between the carboxy of one molecule of salicylic acid with the phenol group of a second. It is a prodrug for salycylic acid that is used for treatment of rheumatoid arthritis and osteoarthritis and also shows activity against type II diabetes. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, a hypoglycemic agent, an antineoplastic agent, an EC 3.5.2.6 (beta-lactamase) inhibitor, an antirheumatic drug and a prodrug. It is a member of benzoic acids, a member of salicylates, a member of phenols and a benzoate ester. It is functionally related to a salicylic acid.
2D Structure
Properties
C14H10O5
Molecular Formula
258.23
Molecular Weight
g/mol
258.0528
Exact Mass
Da
3
XLogP
Drug-like (Lipinski: < 5)
83.8
TPSA
Good oral absorption (< 140 A²)
2
H-Bond Donors
5
H-Bond Acceptors
341
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Salsalate552-94-3sasapyrineSalicylsalicylic acidDisalcid2-Carboxyphenyl salicylateDisalicylic acidSasapyrinumSasapyrin2-(2-hydroxybenzoyl)oxybenzoic acidDisalicylsaeureSalsalato2-((2-Hydroxybenzoyl)oxy)benzoic acidSalicylic acid, bimolecular esterBenzoic acid, 2-hydroxy-, 2-carboxyphenyl ester
Data from PubChem (NCBI)
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Drug Network
Trials and conditions connected to Salsalate
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