Sapropterin dihydrochloride
(6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-3H-pteridin-4-one;dihydrochloride
Molecular Identity
Sapropterin dihydrochloride
(6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-3H-pteridin-4-one;dihydrochloride
PubChem CID: 135409471
Sapropterin dihydrochloride is the dihydrochloride salt of sapropterin. It is used for the diagnosis and treatment of variant forms of phenylketonuria (hyperphenylalaninaemia) associated with tetrahydrobiopterin deficiency. Natural cofactor for phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, and nitric oxide synthetase. It has a role as a coenzyme and a diagnostic agent. It contains a sapropterin.
2D Structure
Properties
C9H17Cl2N5O3
Molecular Formula
314.17
Molecular Weight
g/mol
313.0708
Exact Mass
Da
132
TPSA
Good oral absorption (< 140 A²)
8
H-Bond Donors
6
H-Bond Acceptors
405
Complexity
SMILES
Canonical SMILES
SMILES: Synonyms(20)
Sapropterin dihydrochloride69056-38-8BioptenKuvanSAPROPTERIN HYDROCHLORIDEPhenoptinDapropterin hydrochlorideSUN-0588(6R)-Tetrahydrobiopterin hydrochlorideRG277LF5B3DTXSID0040620T1401T-1401DTXCID8020620CHEBI:32120
Data from PubChem (NCBI)
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